HYACYST with highly purified non-animal based hyaluronic acid content is quite effective in the symptomatic treatment of cystitis.
HYACYST may provides relief in pain and urinary frequency in interstitial cystitis patients.
HYACYST has proven to be effective in the following types of cystitis.
- Interstitial Cystitis
- Cystitis caused by radiation
- Recurrent bacterial cystitis
In Interstitial cystitis / painful bladder syndrome, Hyacyst may significantly decreases the incidence of urine, causes significant reduction in pain scores and may reduce the analgesic use. According to long-term evaluation of the results, reduced pain and urinary frequency in 80% of patients is observed.
In refractory interstitial cystitis, at the end of 4 weeks Hyacyst is effective about 71% and this effect continues 20 weeks.
HYACYST is highly effective in preservation of cystitis caused by radiation.
Hyacyst usage before radiotherapy may,
- Protects the bladder.
- Reduces the risk of infection and the toxicity caused byRadiation.
- Increase the general quality of patient life .
On Pelvic cancer patients,before radiotherapy application, HYACYST may provides a significant protective effect.
Bacterial virulence factors is important in the development of Urinary System infection (USI ). The presence of a perfect GAG layer is considered as the basis for protection of the epithelium cells of the bladder against toxic composition of the urine and studies show that GAG layer prevents bacterial adhesions.
A deficient GAG layer results in direct exposure of epithelial cells to urinary components, in which case there exists the risk for both bacterial adhesion and infections.
In those patients HYACYST may;
- Protects the bladder.
- Decreases the infection risk and toxine.
Intravesical application of hyaluronic acid in patients with hospitalized and spinal cord injury which is characterized by acute urinary retention causes to the decrease 5 to 7 times the rate of infection.
The primary component of HYACYST is sodium hyaluronate, a derivative of hyaluronic acid, which occurs naturally in the fluids of the eye, the joints, and in the glycosaminoglycan (GAG) layer of the bladder lining (Urothel). This layer – which is deficient in many patients with interstitial cystitis – is believed to provide the bladder wall with a protective coating.
What does HYACYST do ?
HYACYST temporarily replaces the deficient GAG layer on the bladder wall, helps to relieve the pain, frequency and urgency. Research has shown that HYACYST can provide relief from these distressing symptoms where other treatments have failed.
How is HYACYST administered ?
HYACYST is instilled directly into the bladder by your urologist. This usually only requires an outpatient visit to your hospital clinic.
How long do I need treatment for ?
For the first four to six weeks of treatment, all patients receive one instillation each week. After that, treatments are usually given once a month until the symptoms resolve. Response time will vary from patient to patient. A good response to HYACYST may mean that instillation is only required every six, eight, or even 12 weeks. However; patients who do not notice an early improvement should not be discouraged, as five or six instillations may be necessary before symptoms begin to resolve. Treatment may be recommenced in the future if symptoms return.
Does HYACYST have any side-effects ?
Research has shown that HYACYST is well tolerated and causes few, if any adverse reactions. Occasionally, some localised irritation has been experienced as a result of the instillation procedure itself, rather than as a side-effect of HYACYST.
How do I obtain treatment with HYACYST ?
Although HYACYST is classified as a medical device, and is therefore not subject to the usual pharmaceutical supply regulations, it does require administration by qualified medical personnel. Furthermore, the decision as to whether or not HYACYST is appropriate for any given patient must lie with the urologist.